![]() ![]() Because MetaCyc contains only experimentally elucidated data, it is a unique and valuable resource. MetaCyc () is a non-redundant reference database of small-molecule metabolism that contains experimentally verified metabolic pathway and enzyme information curated from the scientific literature ( 1 ). The BioCyc PGDBs generated by SRI are offered for adoption by any interested party for the ongoing integration of metabolic and genome-related information about an organism. The BioCyc website offers many tools for computational analysis of PGDBs, including comparative analysis and analysis of omics data in a pathway context. BioCyc PGDBs also contain predicted operons and predicted pathway hole fillers-predictions of which enzymes may catalyze pathway reactions that have not been assigned to an enzyme. Each BioCyc PGDB contains the predicted metabolic network of one organism, including metabolic pathways, enzymes, metabolites and reactions predicted by the Pathway Tools software using MetaCyc as a reference database. BioCyc () is a collection of more than 350 organism-specific Pathway/Genome Databases (PGDBs). Because MetaCyc contains only experimentally elucidated knowledge, it provides a uniquely high-quality resource for metabolic pathways and enzymes. Each reaction in a MetaCyc pathway is annotated with one or more well-characterized enzymes. The pathways in MetaCyc are curated from the primary scientific literature, and are experimentally determined small-molecule metabolic pathways. MetaCyc () is a universal database of metabolic pathways and enzymes from all domains of life.
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